微流控器件中的多相流动

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doi:10.6052/1000-0992-14-063

中国科学院力学研究所非线性力学国家重点实验室, 北京 100190

基金项目:国家自然科学基金(11272321和11402274)和科技部973计划(2011CB707604)项目资助.

详细信息

通讯作者:
胡国庆, 中国科学院力学研究所非线性力学国家重点实验室研究员, 博士生导师. 现任开云棋牌官方副秘书长. 曾在美国、加拿大、英国、以色列等国家长期从事研究工作, 目前开展微纳米流体力学机理和微纳流控芯片设计理论的研究, 侧重于微纳尺度颗粒、细胞、液滴、生物大分子等输运及其在生化领域的应用. 主持国家973 计划、国家自然科学基金、中科院知识创新重要方向项目等多项课题. 在ACS Nano, Lab ona Chip, Biosensors & Bioelectronics, Analytica Chimica Acta, Physicsof Fluids, Biomicrofluidcis, Electrophoresis 等国际重要学术期刊发表SCI论文近40篇.

中图分类号:O359
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出版历程
- 收稿日期:2014-10-08
- 修回日期:2015-01-27
- 刊出日期:2015-08-30

Multiphase flow in microfluidic devices

LNM, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China

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Corresponding author:Guoqing HU

摘要

摘要:微流控技术及微流控器件是近年来发展迅速的多学科交叉研究领域.相比于传统方法, 微流控技术能够实现对微量多相流体的精准操控, 可应用于化学分析、先进材料合成、蛋白质结晶、单细胞培育及检测、信息处理等领域. 该文回顾微流控器件中的多相流动现象, 概述其所涉及的流体力学机理,阐述实现多相微流控的各种方法, 并分析多相微流控技术的应用现状及面临的挑战, 最后总结针对多相微流动问题的数值模拟方法和实验测量技术, 展望多相微流控器件的研究方向及应用前景.
- 微尺度流动/
- 多相流动/
- 液滴/
- 微流控器件
Abstract:Recent years have witnessed the rapid development of microfluidic technology and microfluidic devices as a multi-disciplinary research field. Compared to conventional methods, microfluidic technology enables us to precisely manipulate the small volume of multiphase fluids for chemical analysis, advanced materials synthesis, protein crystalliza-tion, single-cell cultivation and detection, information processing, etc. In this paper, we review the multiphase flow phenomena in microfluidic devices, summarize the fluid mechan-ics involved, describe various methods to achieve multiphase microfluidic flow, and analyze the state-of-the-art of applications and challenges in this field. Finally, numerical simulation methods and experimental measurement techniques for multiphase microflows are provided. Opportunities for future research and application of microfluidic devices are suggested.
- microfluidics/
- multiphase flow/
- droplet/
- microfluidic device

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