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摘要:本文介绍了现代生物力学的发展历程和冯元帧先生的贡献、力学生物学的概念与发展以及我国生物力学的发展历程和力学生物学的研究新进展;思考了从生物力学到力学生物学的进展与现状;展望了我国生物力学学科发展的愿景.Abstract:In the present paper, we introduce the development of biomechanics and the contribution of Dr. Y. C. Fung, the concept and development of mechanobiology, the development of biomechanics, as well as the advance of mechanobiology in China. We reflect the current status and progress from biomechanics to mechanobiology, and further prospect the vision of biomechanics in China.
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Key words:
- biomechanics/
- mechanobiology/
- stress-growth/
- remodeling/
- mechanotransduction
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表 1活组织研究的题目与工具
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[1] 邓小燕, 王贵学. 2002. 动脉系统中致动脉粥样性脂质的浓度极化现象. 中国科学, 32: 559-67http://www.cnki.com.cn/Article/CJFDTOTAL-JCXK200206011.htm [2] 陈槐卿. 1980. 血液流变学及其临床应用. 成都: 四川教育出版社 [3] 冯元帧. 1983. 生物力学. 北京: 科学出版社 [4] 冯元帧. 1986a. 生物力学——活组织的力学特性. 戴克刚, 鞠烽炽, 译. 长沙: 湖南科学技术出版社. [5] 冯元帧. 1986b. 生物动力学——血液循环. 戴克刚, 译. 长沙: 湖南科学技术出版社. [6] 冯元帧. 1993. 生物力学——运动、流动、应力和生长. 邓善熙, 译. 成都: 四川教育出版社. [7] 姜宗来. 2006. 心血管力学生物学研究的新进展. 医用生物力学, 21: 251-253http://www.cnki.com.cn/Article/CJFDTOTAL-YISX200604000.htmJiang Z L. 2006. Recent advances in cardiovascular mechanobiology. J Med Biomech, 21: 251-253http://www.cnki.com.cn/Article/CJFDTOTAL-YISX200604000.htm [8] 姜宗来, 樊瑜波. 2010. 生物力学——从基础到前沿. 北京: 科学出版社Jiang Z L, Fan Y B. 2010. Biomechanics. Beijing: Science Press [9] 姜宗来. 2011. 我国生物力学研究现状与展望. 中国生物医学工程学报, 30: 165-172http://www.cnki.com.cn/Article/CJFDTOTAL-ZSWY201102002.htmJiang Z L. The recent advances and prospects of biomechanics in China. Chinese J Biomed Eng, 30: 165-172http://www.cnki.com.cn/Article/CJFDTOTAL-ZSWY201102002.htm [10] 柳兆荣, 李惜惜. 1998. 血液动力学原理和方法. 上海: 复旦大学出版社 [11] 陶祖莱. 1984. 生物流体力学. 北京: 科学出版社 [12] 陶祖莱. 2000. 生物力学导论. 天津: 天津科技翻译出版社公司. [13] 王以进. 1989. 骨科生物力学. 北京: 人民军医出版社 [14] 翁文良, 廖福龙, 吴云鹏. 1989. 血液流变学研究方法及其应用. 北京: 科学出版社 [15] 吴云鹏, 杨瑞芳. 1987. 体液流变特性. 北京: 科学出版社. [16] 吴云鹏. 1993. 胆道流变学. 重庆: 重庆出版社 [17] Yang G T,Wu W Z. 1989. Bone Mechanics. Beijing:Science Press [18] 杨桂通. 1990. 医用生物力学. 北京: 科学出版社Yang G T. 1990. Medical Biomechanics. Beijing:Science Press [19] Cheng B B, QuMJ,Wu L L, et al. 2014. MicroRNA-34a targets Forkhead Box J2 to modulate differentiation of endothelial progenitor cell in response to shear stress. J Mol Cell Cardio, 74: 4-12 [20] Cheng M, Liu X, Li Y, Tang R, Zhang W, Wu J, Li L, Liu X, Gang Y, Chen H. 2007. IL-8 gene induction by low shear stress: pharmacological evaluation of the role of signaling molecules. Biorheology, 44: 349-360 [21] Cheng M, Guan X, Li H, Cui X D, Zhang X Y, Li X, Jing X, Wu H Y, Avsar E. 2013. Shear stress regulates late EPC differentiation via mechanosensitive molecule-mediated cytoskeletal rearrangement. Plos One, 8: e67675 [22] Chien S, Usami S, Dellenback R L, Gregersen M I. 1967a. Blood Viscosity: Influence of erythrocyte defor-mation. Science, 157: 827-829 [23] Chien S, Usami S, Dellenback R L, Gregersen MI, Nanninga LB, Guest MM. 1967b. Blood Viscosity:Influence of erythrocyte aggregation. Science, 157: 829-831 [24] Chien S. 1970. Shear dependence of effective cell volume as a determinant of blood viscosity. Science, 168:977-978doi:10.1126/science.168.3934.977 [25] Chien S. 2007. Mechanotrasduction and endothelial cell homeostasis: the wisdom of the cell. Am J Physiol Heart Circ Physiol, 292: H1209-H1224http://cn.bing.com/academic/profile?id=808e6c7f57b55959ac808f8bd09c4ea6&encoded=0&v=paperpreview&mkt=zh-cn [26] Chiu J J, Usami S, Chien S. 2009. Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis. Ann Med, 41: 19-28doi:10.1080/07853890802186921 [27] Du J, Chen X F, Liang X D, Zhang G, Xu J, He L, Zhan Q, Feng X Q, Chien S, Yang C. 2011. Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc Natl Acad Sci USA, 108: 9466-9471doi:10.1073/pnas.1106467108 [28] Du J, Zu Y, Du S Y, Xu Y, Zhang L, Jiang L, Wang Z, Chien S, Yang C. 2016. Extracellular matrix stiffness dictates Wnt expression through integrin pathway. Sci Rep, 6: 20395doi:10.1038/srep20395 [29] Engler A J, Sen S, Sweeney H L, Discher D E. 2006. Matrix elasticity directs stem cell lineage specification.Cell, 126: 677-689doi:10.1016/j.cell.2006.06.044 [30] Fung Y C. 1981. Biomechanics: Mechanical Properties of Living Tissues. 2nd edn. Springer-Verlag New York Inc. [31] Fung Y C. 1984. Biodynamics: Circulation. Springer-Verlag New York Inc. [32] Fung Y C, Liu S Q. 1989. Change of residual stress in arteries due to hypertrophy caused by aortic constriction. Circ Res, 65: 1340-1349doi:10.1161/01.RES.65.5.1340 [33] Fung Y C. 1990. Biomechanics: Motion, Flow, and Growth. Springer-Verlag New York Inc. [34] Fung Y C, Liu S Q. 1991. Changes of zero-stress state of rat pulmonary arteries in hypoxic hypertension. J Appl Physiol, 70: 2455-2470doi:10.1063/1.349398 [35] Fung Y C. 1993. Biomechanics: Mechanical Properties of Living Tissues. 2nd edn. Springer-Verlag New York Inc. [36] Fung Y C. 1996. Biomechanics: Circulation. 2ed, Springer-Verlag New York Inc. [37] Fung Y C. 2002. Celebrating the inauguration of the journal: Biomechanics and modeling in mechanobiology. Biomechan Model Machanobiol, 1: 3-4doi:10.1007/s10237-002-0006-z [38] Gong H, Zhang M, Fan Y B, KwokWL, Leung P C. 2012. Relationships between femoral strength evaluated by nonlinear finite element analysis and BMD, material distribution and geometric morphology. Ann Biomed Eng, 40: 1575-1585. [39] Han Y, Wang L, Yao Q P, Zhang P, Liu B, Wang G L, Shen B R, Cheng B, Wang Y, Jiang Z L, Qi Y X. 2015. Nuclear envelope proteins Nesprin2 and LaminA regulate proliferation and apoptosis of vascular endothelial cells in response to shear stress. BBA Mol Cell Res, 1853: 1165-1173https://www.researchgate.net/publication/272753862_Nuclearenvelopeproteins_Nesprin2and_LaminAregulateproliferationandapoptosisofvascularendothelialcellsinresponsetoshearstress?sg=N9AKap9--TwcNP5SFWK8Ul1fkflvUJ9wk0SXRg1rVub7QmnThgx6wTfgp6mamVTZfl6miHI33jTX5dHTmS8hhPAW8tQ7RDxZ424HShnyjk [40] He M, Liang X, He L, Wen W, Zhao S, Wen L, Liu Y, Shyy J Y, Yuan Z. 2013. Endothelial dysfunction in rheumatoid arthritis: the role of monocyte chemotactic protein-1-induced protein. Arterioscler Thromb Vasc Biol, 33: 1384-1391.http://cn.bing.com/academic/profile?id=501562a8919d32da90b89e792249c628&encoded=0&v=paperpreview&mkt=zh-cn [41] Huang W, Sher Y P, Peck K, Fung Y C. 2002. Matching gene activity with physiological functions. Proc Natl Acad Sci USA, 99: 2603-2608. [42] Jiang J, Qi Y X, Zhang P, Gu W T, Yan Z Q, Shen B R, Yao Q P, Kong H, Chien S, Jiang Z L. 2013. Involvement of Rab28 in NF-кB nuclear transport in endothelial cells. Plos One, 8: e56076doi:10.1371/journal.pone.0056076 [43] Jiang Z L, Kassab G S, Fung Y C. 1994. Diameter-defined strahler system and connectivity matrix of the pulmonary arterial tree. J Appl Physiol, 76: 882-892https://www.researchgate.net/publication/15022865_Diameter-defined_Strahlersystemandconnectivitymatrixofthepulmonaryarterialtree [44] Kang H, Fan Y, Deng X. 2011. Vascular smooth muscle cell glycocalyx modulates shear-induced proliferation, migration, and no production responses. Am J Physiol Heart Circ Physiol, 300: H76-H83doi:10.1152/ajpheart.00905.2010 [45] Kang H, Fan Y, Sun A, Jia X, Deng X. 2013. Simulated microgravity exposure modulates the phenotype of cultured vascular smooth muscle cells. Cell Biochem Biophys, 66: 121-130doi:10.1007/s12013-012-9460-0 [46] Li H, Li R X, Wan Z M, Xu C, Li J Y, Hao Q X, Guo Y, Liu L, Zhang X Z. 2013. Counter-effect of constrained dynamic loading on osteoporosis in ovariectomized mice. J Biomech, 46: 1242-1247doi:10.1016/j.jbiomech.2013.02.016 [47] Liu L, Guo Y, Chen X Z, Li R, Li Z, Wang L, Wan Z, Li J, Hao Q, Li H, Zhang X. 2012. Three-dimensional dynamic culture of pre-osteoblasts seeded in HA-CS/Col/nHAP composite scaffolds and treated with ff-ZAL. Acta Biochim Biophys Sin, 44: 669-677doi:10.1093/abbs/gms049 [48] Li L, Qian Y, Jiang C, Lv Y, Liu W, et al. 2012. The use of hyaluronan to regulate protein adsorption and cell infiltration in nanofibrous scaffolds. Biomaterials, 33: 3428-3445doi:10.1016/j.biomaterials.2012.01.038 [49] Li L, Puhl S, Meinel L, Germershaus O. 2014. Silk fibroin layer-by-layer microcapsules for localized gene delivery. Biomaterials, 35: 7929-7939doi:10.1016/j.biomaterials.2014.05.062 [50] Li L, Zhang J, Xiong N, Li S, Chen Y, Yang H,Wu C K, Zeng H J, Liu Y Y. 2016a. Notch-1 signaling activates NF-kB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent PI3K/AKT pathway. Med Oncol, 33: 1-11doi:10.1007/s12032-015-0714-8 [51] Li S, Lu J, Chen Y, Xiong N, Li L, Zhang J, Yang H, Wu C, Zeng H, Liu Y. 2016b. MCP-1-triggered ERK/GSK-3beta/Snail pathway facilitates epithelial-mesenchymal transition and promotes cell migration of human breast carcinoma MCF-7 cells. Cell Mol Immunol, 13: 1-10doi:10.1038/cmi.2015.94 [52] Li Y, Xu G K, Li B, Feng X Q. 2010. A molecular mechanisms-based biophysical model for two-phase cell spreading. Appl Phys Lett, 96: 043703doi:10.1063/1.3298361 [53] Li Z J, Huang W, Jiang Z L, Gregersen H, Fung Y C. 2004. Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension. Proc Natl Acad Sci USA, 101: 11488-1149doi:10.1073/pnas.0404084101 [54] Liu X, Fan Y, Deng X. 2011. Mechanotransduction of flow-induced shear stress by endothelial glycocalyx fibers is torque determined. ASAIO J, 57: 487-94doi:10.1097/MAT.0b013e318233b5ed [55] Liu X, Pu F, Fan Y, Deng X, Li D, Li S. 2009. A numerical study on the flow of blood and the transport of LDL in the human aorta: the physiological significance of the helical flow in the aortic arch. Am J Physiol Heart Circ Physiol, 297: H163-H170doi:10.1152/ajpheart.00266.2009 [56] Liu Y, Tian XY, Mao G, Fang X, Fung ML, Shyy JY, Huang Y, Wang N. 2012. Peroxisome proliferator-activated receptor-fl ameliorates pulmonary arterial hypertension by inhibiting 5-hydroxytryptamine 2B receptor. Hypertension, 60: 1471-1478doi:10.1161/HYPERTENSIONAHA.112.198887 [57] Luo Z, Jiang L, Xu Y, Li H, Xu W, Wu S, Wang Y, Tang Z, Lv Y, Yang L. 2015. Mechano growth factor(MGF) and transforming growth factor (TGF)-3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model. Biomaterials, 52: 463-475doi:10.1016/j.biomaterials.2015.01.001 [58] Qi Y X, Qu M J, Long D K, Liu B, Yao QP, Chien S, Jiang Z L. 2008. Rho-GDI alpha downregulated by low shear stress promotes vascular smooth muscle cell migration and apoptosis: A proteomic analysis. Cardiovasc Res, 80: 114-122doi:10.1093/cvr/cvn158 [59] Qi Y X, Jiang J, Jiang X H, Wang X D, Ji SY, Han Y, Long D K, Shen B R, Yan Z Q, Chien S, Jiang Z L. 2011. Paracrine control of PDGF-BB and TGFfi1 on cross-talk between endothelial cells and vascular smooth muscle cells during low shear stress induced vascular remodeling. Proc Natl Acad Sci USA, 108:1908-1913doi:10.1073/pnas.1019219108 [60] Qi Y X, Yao Q P, Huang K, et al. 2016. Nuclear envelope proteins modulate proliferantion of vascular smooth muscle cells during cyclic stretch application. Proc Natl Acad Sci USA, 113: 5293-5298doi:10.1073/pnas.1604569113 [61] Qiu J, Peng Q, Zheng Y, Hu J, Luo X, Teng Y, Jiang T, Yin T, Tang C, Wang G. 2012. OxLDL stimulates Id1 nucleocytoplasmic shuttling in endothelial cell angiogenesis via PI3K Pathway. BBA Mol Cell Biol, 1821: 1361-1369https://www.researchgate.net/publication/230581243_OxLDLstimulates_Id1nucleocytoplasmicshuttlinginendothelialcellangiogenesisvia_PI3K_Pathway [62] Qiu J, Wang G, Zheng Y, Hu J, Peng Q, Yin T. 2011. Coordination of Id1 and p53 activation by oxidized LDL regulates endothelial cell proliferation and migration. Ann Biomed Eng, 39: 2869-2878doi:10.1007/s10439-011-0382-6 [63] Shyy J Y J, Chien S. 1997. Role of integrins in cellular responses to mechanical stress and adhesion. Cur Opin Cell Biol, 9: 707-713doi:10.1016/S0955-0674(97)80125-1 [64] Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy J Y, Zhu Y. 2016. Activation of integrin ff5 mediated by flow requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci USA, 113: 769-774doi:10.1073/pnas.1524523113 [65] Wan X J, Zhao H C, Zhang P, Huo B, Shen B R, Yan Z Q, Qi Y X, Jiang Z L. 2015. Involvement of BK channel in differentiation of vascular smooth muscle cells induced by mechanical stretch. Int J Biochem Cell Biol, 59: 21-29doi:10.1016/j.biocel.2014.11.011 [66] Wang L, Li J Y, Zhang X Z, Liu L, Wang Z M, Li R X, Guo Y. 2012. Innvolvement of p38MAPK/NF-Kb signaling parhways in osteoblasts differentiation in response to mechanical stretch. Ann Biomed Eng, 40:1884-1894doi:10.1007/s10439-012-0548-x [67] Wang Y, Tang Z, Xue R, Singh G K, Shi K, Lv Y, Yang L. 2011. Combined effects of TNF-, IL-1, and HIF-1? on MMP-2 production in ACL fibroblasts under mechanical stretch: an in vitro study. J Orthop Res, 29: 1008-1014doi:10.1002/jor.21349 [68] Wang Y X, Botvinick E, Zhao Y H, Berns M W, Usami S, Tsien RY, Chien S. 2005. Visualizing the mechanical activation of Src. Nature, 434: 1040-1045doi:10.1038/nature03469 [69] Wang Z Z, Liu X, Kang H Y, Sun A, Fan Y, Deng X. 2014. Enhanced accumulation of LDLs within the venous graft wall induced by elevated filtration rate may account for its accelerated atherogenesis. Atherosclerosis, 236: 198-206doi:10.1016/j.atherosclerosis.2014.07.006 [70] Wang X, Fang X, Zhou J, Chen Z, Zhao B, Xiao L, Liu A, Li Y S, Shyy J Y, Guan Y, Chien S, Wang N. 2013. Shear stress activation of nuclear receptor PXR in endothelial detoxification. Proc Natl Acad Sci USA, 110: 13174-13179doi:10.1073/pnas.1312065110 [71] Wen L, Chen Z, Zhang F, et al. 2013. Ca2+/calmodulin-dependent protein kinase kinase fi phosphorylation of Sirtuin 1 in endothelium is theroprotective. Proc Natl Acad Sci USA, 110: E2420-E2407doi:10.1073/pnas.1309354110 [72] Wu Y, Zhang X, Zhang P, Fang B, Jiang L. 2012. Intermittent traction stretch promotes the osteoblastic differentiation of bone mesenchymal stem cells by the ERK1/2-activated Cbfa1 pathway. Connect Tissue Res, 53: 451-459doi:10.3109/03008207.2012.702815 [73] Xie J, Wang C, Huang D Y, Zhang Y, Xu J, Kolesnikov S S, Sung K L, Zhao H. 2013. TGF-beta1 induces the different expression of lysyl oxidases and matrix metalloproteinases in anterior crcuaite ligament and medial collateral ligament fibroblasts after mechanical injury. J Biomech, 46: 890-898doi:10.1016/j.jbiomech.2012.12.019 [74] Xu G K, Yang C, Du J, Feng X Q. 2014. Integrin activation and internalization mediated by extracellular matrix elasticity: A biomechanical model. J Biomech, 47: 1479-1487doi:10.1016/j.jbiomech.2014.01.022 [75] Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y. 2016. Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget, 7: 16227-16247https://www.researchgate.net/publication/296055323_Mechanosensitivecaveolin-1activation-induced_PI3KAktmTORsignalingpathwaypromotesbreastcancermotilityinvadopodiaformationandmetastasisinvivo [76] Yang Z, Xia W H, Zhang Y Y, Xu SY, Liu X, Zhang X Y, Yu B B, Qiu Y X, Tao J. 2012. Shear stress-induced activation of Tie2-dependent signaling pathway enhances reendothelialization capacity of early endothelial progenitor cells. J Mol Cell Cardiol, 52: 1155-1163doi:10.1016/j.yjmcc.2012.01.019 [77] Yang Y C,Wang X D, Huang K,Wang L, Jiang Z L, Qi Y X. 2014. Temporal phosphoproteomics to investiate the mechanotransduction of vascular smooth muscle cells in response to cyclic stretch. J Biomech, 47:3622-3629doi:10.1016/j.jbiomech.2014.10.008 [78] Zeng Y, Sun H R, Yu C, Lai Y, Liu X J, Wu J, Chen H Q, Liu X H. 2011. CXCR1 and CXCR2 are novel mechano-sensors mediating laminar shear stress-induced endothelial cell migration. Cytokine, 53: 42-51doi:10.1016/j.cyto.2010.09.007 [79] Zhang P, Wu Y, Jiang Z, Jiang L,Fang B. 2012. Osteogenic responses of bone mesenchymal stem cells to continuous mechanical strain is dependent on ERK1/2-Runx2 signaling. Int J Mol Med, 29: 1083-1089 [80] Zhang P, Wu Y, Dai Q, Fang B,Jiang. 2013. p38-MAPK signaling pathway is not involved in osteogenic differentiation during early response of mesenchymal stem cells to continuous mechanical strain. Mol Cell Biochem, 378: 19-28doi:10.1007/s11010-013-1589-7 [81] Zhao F, Li L, Guan L, Yang H,Wu C, Liu Y. 2014. Roles of GP IIb/IIIa and ffvfi3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. Cancer Lett, 344: 62-73doi:10.1016/j.canlet.2013.10.019 [82] Zhou J, Li Y S, Nguyen P, Wang K C, Weiss A, Kuo Y C, Chiu J J, Shyy J Y, Chien S. 2013. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: Role of shear stress. Circ Res, 113: 40-51doi:10.1161/CIRCRESAHA.113.280883