肿瘤及其微环境的力学问题

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doi:10.6052/1000-0992-16-039

施兴华^1,2,ɛ,,,
张路姚^1,2,3,
李博⁴,
冯西桥^4,’,,

1 国家纳米科学中心中国科学院纳米系统与多级次制造重点实验室, 北京 100190
2 中国科学院大学, 北京 100049
3 中国科学院力学研究所非线性力学国家重点实验室, 北京 100190
4 清华大学工程力学系生物力学与医学工程研究所, 北京 100084

基金项目:国家自然科学基金项目资助 (11422215, 11272327, 11672079, 11432008,11620101001)

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作者简介:
null

作者简介：
施兴华, 国家纳米科学中心研究员, 博士生导师, 中国科学院大学岗位教授. 2001年本科毕业于北京大学力学与工程科学系, 2004年获中国科学院力学研究所硕士学位, 2010年获美国布朗大学博士学位, 2010年12月在中国科学院力学研究所任副研究员, 2016年3月加入国家纳米科学中心工作.近期主要从事力学与纳米材料、生物科学交叉领域的研究工作.2014年获基金委优秀青年基金.
李博, 清华大学工程力学系副教授, 博士生导师.2004年、2007年先后于湖南大学工程力学系获学士、硕士学位, 2011年获清华大学工程力学系博士学位.2011年9月至2014年8月在美国约翰\(\cdot\)霍普金斯大学从事博士后研究工作.2015年5月加入清华大学工程力学系工作.主要研究方向为生物软组织力学、细胞力学.曾获2013年全国优秀博士学位论文奖, 2015年入选中组部"青年千人计划".
冯西桥, 1968年生.现任清华大学工程力学系主任、生物力学与医学工程研究所所长、长江学者特聘教授.1990年7月、1991年7月和1995年3月先后在清华大学工程力学系获学士、硕士和博士学位.1997年6月清华大学核研院博士后出站. 之后获洪堡奖学金, 在德国Darmstadt工业大学和荷兰Delft工业大学任洪堡研究员.1999年回国, 在清华大学工程力学系任副教授, 2001年任教授.其主要研究方向是生物材料力学、损伤与断裂力学, 发表SCI论文约200篇、专著3部.曾获中国青年科技奖、国家杰出青年科学基金、全国优秀博士学位论文奖及指导教师奖等奖励.

通讯作者:
施兴华
冯西桥

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出版历程
- 收稿日期:2016-11-08
- 刊出日期:2018-02-08

The mechanical problems in tumor and tumor microenvironment

SHI Xinghua^1,2,ɛ,,,
ZHANG Luyao^1,2,3,
LI Bo⁴,
FENG Xiqiao^4,’,,

1 CAS Key Laboratory for Nanosystem and Hierarchy Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China
2 University of Chinese Academy of Science, Beijing 100049, China
3 LNM, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China
4 Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China

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^’E-mail:fengxq@tsinghua.edu.cn
^ɛE-mail:shixh@nanoctr.cn

Corresponding author:SHI Xinghua;FENG Xiqiao

摘要

摘要:肿瘤微环境包括肿瘤细胞、间质细胞、细胞外基质等.其在肿瘤的生长和发展过程中起着关键作用.肿瘤的微环境与正常组织的微环境有着显著的不同.肿瘤中的压应力对微环境有着多方面的影响, 例如, 可调控血管与淋巴管的功能, 造成代谢异常和间质高压, 压缩间隙基质, 增大药物输运的困难, 促进间质细胞变异并诱导肿瘤细胞转移. 因此, 肿瘤中的力学因素引起了广泛关注.本文总结了肿瘤及其微环境力学问题的研究进展, 讨论了肿瘤微环境中应力产生、药物输运、肿瘤转移等问题, 介绍了肿瘤微环境正常化的策略及其对肿瘤治疗的意义.
- 肿瘤微环境/
- 生物力学/
- 应力/
- 药物输运/
- 肿瘤转移参考文献
Abstract:Tumor microenvironment contains tumor cells, stromal cells and extracellular matrix, which plays an important role in tumor growth and development. The tumor microenvironment has its unique structural features. Physical forces in tumors can change the tumor microenvironment, disable the blood and lymphatic vessels, result in the abnormal metabolism, compress the interstitial structure, hinder the delivery of drugs, and induce stromal cells to change their behavior and promote tumor metastasis. So the forces in tumor have attracted increasing attention. In this review, we summarize the advances of mechanics problems in tumor and its microenvironments. We discuss the causes of solid stress, drug delivery and tumor metastasis. Also we introduce several strategies to restore the tumor microenvironments and their effects on tumor therapy.
- tumor microenvironment/
- biomechanics/
- solid stress/
- drug delivery/
- metastasis

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参考文献 (295)

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