A REVIEW ON MECHANOBIOLOGY MECHANISM OF BONE FORMATION AND REMODELING
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摘要:生物力学已被证实是骨组织生长、重建及成形当中一个十分重要的因素. 骨组织的损伤修复过程本质上是细胞的生物学过程和应力作用下的生长过程. 这虽然肯定了生物力学在骨组织生长、重建过程中的重要地位, 但是, 人们对生物力学因素如何诱导骨生长、重建的力学生物学机制仍不甚了解. 而骨组织工程需要更为科学完善的细胞生物学机制来研究和探索骨组织的构建过程. 本文概述了国内外生物力学与骨组织生长重建的宏微观理论, 主要讨论了骨组织结构及功能形成过程中的力学生物学相关问题.
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关键词:
- 生物力学, 骨组织, 力学生物学
Abstract:Biomechanics plays a critical role in studies on bonegrowth, remodeling and formation. The essence of bone tissue injury andrepair is the cellular process of bone growth under straining. Although weare well aware of the importance of biomechanics in bone developing andremodeling, the mechanobiological mechanisms of the bone growth inducedand remodeled, which are necessary for the study of bone tissue engineeringin vitro, remain poorly understood. In this paper, we review the recentprogresses of bone biomechanics study, focusing on the relationship betweenbiomechanics and bone growth.-
Key words:
- biomechanics, bone, mechanobiology
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