Abstract: The Eulerian and Lagrangian method are used tonumerically simulate the transport and deposition of nanoparticle in humannasal cavity with finite volume method. The k-w turbulence model is used toget the flow field, and one-way coupling Lagrangian method is used to trackthe trajectory of nanoparticle with Stokes, Brownian and thermophoreticforce considered in this model. It's found that Deposition in the nasalcavity is high for very small nanoparticles. The particle diameter range inwhich the deposition drops from 80% to 18% is between 1,nm and 10,nm.From 10,nm to 150,nm however, there is only a small change in the depositioncurve from 18% to 5%. These results are helpful to develop themedicine the disease of human nasal cavity.